Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology

Small molecule polyamines participate in diverse aspects of cell growth and differentiation and are known to regulate ion channel gating. Here authors reveal that cellular polyamines control nicotinic acetylcholine receptor (nAChR) biogenesis, and either catabolic degradation or inhibition of polyam...

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Autores principales:	Madhurima Dhara, Jose A. Matta, Min Lei, Daniel Knowland, Hong Yu, Shenyan Gu, David S. Bredt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a4d43b266fe844dd9fdeb0819c48ee18
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spelling	oai:doaj.org-article:a4d43b266fe844dd9fdeb0819c48ee182021-12-02T17:50:40ZPolyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology10.1038/s41467-020-16629-32041-1723https://doaj.org/article/a4d43b266fe844dd9fdeb0819c48ee182020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16629-3https://doaj.org/toc/2041-1723Small molecule polyamines participate in diverse aspects of cell growth and differentiation and are known to regulate ion channel gating. Here authors reveal that cellular polyamines control nicotinic acetylcholine receptor (nAChR) biogenesis, and either catabolic degradation or inhibition of polyamine production augments nAChR assembly.Madhurima DharaJose A. MattaMin LeiDaniel KnowlandHong YuShenyan GuDavid S. BredtNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Madhurima Dhara Jose A. Matta Min Lei Daniel Knowland Hong Yu Shenyan Gu David S. Bredt Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology
description	Small molecule polyamines participate in diverse aspects of cell growth and differentiation and are known to regulate ion channel gating. Here authors reveal that cellular polyamines control nicotinic acetylcholine receptor (nAChR) biogenesis, and either catabolic degradation or inhibition of polyamine production augments nAChR assembly.
format	article
author	Madhurima Dhara Jose A. Matta Min Lei Daniel Knowland Hong Yu Shenyan Gu David S. Bredt
author_facet	Madhurima Dhara Jose A. Matta Min Lei Daniel Knowland Hong Yu Shenyan Gu David S. Bredt
author_sort	Madhurima Dhara
title	Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology
title_short	Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology
title_full	Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology
title_fullStr	Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology
title_full_unstemmed	Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology
title_sort	polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a4d43b266fe844dd9fdeb0819c48ee18
work_keys_str_mv	AT madhurimadhara polyamineregulationofionchannelassemblyandimplicationsfornicotinicacetylcholinereceptorpharmacology AT joseamatta polyamineregulationofionchannelassemblyandimplicationsfornicotinicacetylcholinereceptorpharmacology AT minlei polyamineregulationofionchannelassemblyandimplicationsfornicotinicacetylcholinereceptorpharmacology AT danielknowland polyamineregulationofionchannelassemblyandimplicationsfornicotinicacetylcholinereceptorpharmacology AT hongyu polyamineregulationofionchannelassemblyandimplicationsfornicotinicacetylcholinereceptorpharmacology AT shenyangu polyamineregulationofionchannelassemblyandimplicationsfornicotinicacetylcholinereceptorpharmacology AT davidsbredt polyamineregulationofionchannelassemblyandimplicationsfornicotinicacetylcholinereceptorpharmacology
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Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology

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