A Citrus Fruit Extract High in Polyphenols Beneficially Modulates the Gut Microbiota of Healthy Human Volunteers in a Validated In Vitro Model of the Colon

The effect of a Citrus Fruit Extract high in the polyphenols hesperidin and naringin (CFE) on modulation of the composition and activity of the gut microbiota was tested in a validated, dynamic in vitro model of the colon (TIM-2). CFE was provided at two doses (250 and 350 mg/day) for 3 days. CFE le...

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Autores principales:	Mônica Maurer Sost, Sanne Ahles, Jessica Verhoeven, Sanne Verbruggen, Yala Stevens, Koen Venema
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Roseburia</i> Citrus Fruit Extract gut microbiota short-chain fatty acids (SCFA) in vitro model TIM-2 Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/a4d49a6589cf4d2d97921384ba92801f
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spelling	oai:doaj.org-article:a4d49a6589cf4d2d97921384ba92801f2021-11-25T18:35:14ZA Citrus Fruit Extract High in Polyphenols Beneficially Modulates the Gut Microbiota of Healthy Human Volunteers in a Validated In Vitro Model of the Colon10.3390/nu131139152072-6643https://doaj.org/article/a4d49a6589cf4d2d97921384ba92801f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3915https://doaj.org/toc/2072-6643The effect of a Citrus Fruit Extract high in the polyphenols hesperidin and naringin (CFE) on modulation of the composition and activity of the gut microbiota was tested in a validated, dynamic in vitro model of the colon (TIM-2). CFE was provided at two doses (250 and 350 mg/day) for 3 days. CFE led to a dose-dependent increase in <i>Roseburia</i>, <i>Eubacterium ramulus</i>, and <i>Bacteroides eggerthii</i>. There was a shift in production of short-chain fatty acids, where acetate production increased on CFE, while butyrate decreased. In overweight and obesity, acetate has been shown to increase fat oxidation when produced in the distal gut, and stimulate secretion of appetite-suppressive neuropeptides. Thus, the data in the in vitro model point towards mechanisms underlying the effects of the polyphenols in CFE with respect to modulation of the gut microbiota, both in composition and activity. These results should be confirmed in a clinical trial.Mônica Maurer SostSanne AhlesJessica VerhoevenSanne VerbruggenYala StevensKoen VenemaMDPI AGarticle<i>Roseburia</i>Citrus Fruit Extractgut microbiotashort-chain fatty acids (SCFA)in vitro modelTIM-2Nutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3915, p 3915 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Roseburia</i> Citrus Fruit Extract gut microbiota short-chain fatty acids (SCFA) in vitro model TIM-2 Nutrition. Foods and food supply TX341-641
spellingShingle	<i>Roseburia</i> Citrus Fruit Extract gut microbiota short-chain fatty acids (SCFA) in vitro model TIM-2 Nutrition. Foods and food supply TX341-641 Mônica Maurer Sost Sanne Ahles Jessica Verhoeven Sanne Verbruggen Yala Stevens Koen Venema A Citrus Fruit Extract High in Polyphenols Beneficially Modulates the Gut Microbiota of Healthy Human Volunteers in a Validated In Vitro Model of the Colon
description	The effect of a Citrus Fruit Extract high in the polyphenols hesperidin and naringin (CFE) on modulation of the composition and activity of the gut microbiota was tested in a validated, dynamic in vitro model of the colon (TIM-2). CFE was provided at two doses (250 and 350 mg/day) for 3 days. CFE led to a dose-dependent increase in <i>Roseburia</i>, <i>Eubacterium ramulus</i>, and <i>Bacteroides eggerthii</i>. There was a shift in production of short-chain fatty acids, where acetate production increased on CFE, while butyrate decreased. In overweight and obesity, acetate has been shown to increase fat oxidation when produced in the distal gut, and stimulate secretion of appetite-suppressive neuropeptides. Thus, the data in the in vitro model point towards mechanisms underlying the effects of the polyphenols in CFE with respect to modulation of the gut microbiota, both in composition and activity. These results should be confirmed in a clinical trial.
format	article
author	Mônica Maurer Sost Sanne Ahles Jessica Verhoeven Sanne Verbruggen Yala Stevens Koen Venema
author_facet	Mônica Maurer Sost Sanne Ahles Jessica Verhoeven Sanne Verbruggen Yala Stevens Koen Venema
author_sort	Mônica Maurer Sost
title	A Citrus Fruit Extract High in Polyphenols Beneficially Modulates the Gut Microbiota of Healthy Human Volunteers in a Validated In Vitro Model of the Colon
title_short	A Citrus Fruit Extract High in Polyphenols Beneficially Modulates the Gut Microbiota of Healthy Human Volunteers in a Validated In Vitro Model of the Colon
title_full	A Citrus Fruit Extract High in Polyphenols Beneficially Modulates the Gut Microbiota of Healthy Human Volunteers in a Validated In Vitro Model of the Colon
title_fullStr	A Citrus Fruit Extract High in Polyphenols Beneficially Modulates the Gut Microbiota of Healthy Human Volunteers in a Validated In Vitro Model of the Colon
title_full_unstemmed	A Citrus Fruit Extract High in Polyphenols Beneficially Modulates the Gut Microbiota of Healthy Human Volunteers in a Validated In Vitro Model of the Colon
title_sort	citrus fruit extract high in polyphenols beneficially modulates the gut microbiota of healthy human volunteers in a validated in vitro model of the colon
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a4d49a6589cf4d2d97921384ba92801f
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A Citrus Fruit Extract High in Polyphenols Beneficially Modulates the Gut Microbiota of Healthy Human Volunteers in a Validated In Vitro Model of the Colon

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