Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties

The cytoplasmic protein FROUNT can bind to chemokine receptors and enhance chemokine signalling. Here, the authors show that inhibiting FROUNT in macrophages either by knockdown of the gene or using the anti-alcoholism drug disulfiram, results in a reduction in tumour growth.

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Autores principales:	Yuya Terashima, Etsuko Toda, Meiji Itakura, Mikiya Otsuji, Sosuke Yoshinaga, Kazuhiro Okumura, Francis H. W. Shand, Yoshihiro Komohara, Mitsuhiro Takeda, Kana Kokubo, Ming-Chen Chen, Sana Yokoi, Hirofumi Rokutan, Yutaka Kofuku, Koji Ohnishi, Miki Ohira, Toshihiko Iizasa, Hirofumi Nakano, Takayoshi Okabe, Hirotatsu Kojima, Akira Shimizu, Shiro Kanegasaki, Ming-Rong Zhang, Ichio Shimada, Hiroki Nagase, Hiroaki Terasawa, Kouji Matsushima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a4d75cebbb8f47a985d666129063bb6d
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spelling	oai:doaj.org-article:a4d75cebbb8f47a985d666129063bb6d2021-12-02T15:33:50ZTargeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties10.1038/s41467-020-14338-52041-1723https://doaj.org/article/a4d75cebbb8f47a985d666129063bb6d2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14338-5https://doaj.org/toc/2041-1723The cytoplasmic protein FROUNT can bind to chemokine receptors and enhance chemokine signalling. Here, the authors show that inhibiting FROUNT in macrophages either by knockdown of the gene or using the anti-alcoholism drug disulfiram, results in a reduction in tumour growth.Yuya TerashimaEtsuko TodaMeiji ItakuraMikiya OtsujiSosuke YoshinagaKazuhiro OkumuraFrancis H. W. ShandYoshihiro KomoharaMitsuhiro TakedaKana KokuboMing-Chen ChenSana YokoiHirofumi RokutanYutaka KofukuKoji OhnishiMiki OhiraToshihiko IizasaHirofumi NakanoTakayoshi OkabeHirotatsu KojimaAkira ShimizuShiro KanegasakiMing-Rong ZhangIchio ShimadaHiroki NagaseHiroaki TerasawaKouji MatsushimaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuya Terashima Etsuko Toda Meiji Itakura Mikiya Otsuji Sosuke Yoshinaga Kazuhiro Okumura Francis H. W. Shand Yoshihiro Komohara Mitsuhiro Takeda Kana Kokubo Ming-Chen Chen Sana Yokoi Hirofumi Rokutan Yutaka Kofuku Koji Ohnishi Miki Ohira Toshihiko Iizasa Hirofumi Nakano Takayoshi Okabe Hirotatsu Kojima Akira Shimizu Shiro Kanegasaki Ming-Rong Zhang Ichio Shimada Hiroki Nagase Hiroaki Terasawa Kouji Matsushima Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
description	The cytoplasmic protein FROUNT can bind to chemokine receptors and enhance chemokine signalling. Here, the authors show that inhibiting FROUNT in macrophages either by knockdown of the gene or using the anti-alcoholism drug disulfiram, results in a reduction in tumour growth.
format	article
author	Yuya Terashima Etsuko Toda Meiji Itakura Mikiya Otsuji Sosuke Yoshinaga Kazuhiro Okumura Francis H. W. Shand Yoshihiro Komohara Mitsuhiro Takeda Kana Kokubo Ming-Chen Chen Sana Yokoi Hirofumi Rokutan Yutaka Kofuku Koji Ohnishi Miki Ohira Toshihiko Iizasa Hirofumi Nakano Takayoshi Okabe Hirotatsu Kojima Akira Shimizu Shiro Kanegasaki Ming-Rong Zhang Ichio Shimada Hiroki Nagase Hiroaki Terasawa Kouji Matsushima
author_facet	Yuya Terashima Etsuko Toda Meiji Itakura Mikiya Otsuji Sosuke Yoshinaga Kazuhiro Okumura Francis H. W. Shand Yoshihiro Komohara Mitsuhiro Takeda Kana Kokubo Ming-Chen Chen Sana Yokoi Hirofumi Rokutan Yutaka Kofuku Koji Ohnishi Miki Ohira Toshihiko Iizasa Hirofumi Nakano Takayoshi Okabe Hirotatsu Kojima Akira Shimizu Shiro Kanegasaki Ming-Rong Zhang Ichio Shimada Hiroki Nagase Hiroaki Terasawa Kouji Matsushima
author_sort	Yuya Terashima
title	Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
title_short	Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
title_full	Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
title_fullStr	Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
title_full_unstemmed	Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
title_sort	targeting frount with disulfiram suppresses macrophage accumulation and its tumor-promoting properties
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a4d75cebbb8f47a985d666129063bb6d
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Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties

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