Loss of central auditory processing in a mouse model of Canavan disease.

Loss of central auditory processing in a mouse model of Canavan disease.

Canavan Disease (CD) is a leukodystrophy caused by homozygous null mutations in the gene encoding aspartoacylase (ASPA). ASPA-deficiency is characterized by severe psychomotor retardation, and excessive levels of the ASPA substrate N-acetylaspartate (NAA). ASPA is an oligodendrocyte marker and it is...

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Main Authors: Georg von Jonquieres, Kristina E Froud, Claudia B Klugmann, Ann C Y Wong, Gary D Housley, Matthias Klugmann
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/a4defe9bf1c8429dae4aabbe4823e2b9
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