Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

HIF-1α is a pivotal protein involved in angiogenesis and is known to be regulated posttranslationally. Here, the authors show that HIF-1α is methylated by Set7/9 methyltransferase, which reduces protein stability and contributes to reduced angiogenesis.

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Autores principales: Yunho Kim, Hye Jin Nam, Junyeop Lee, Do Young Park, Chan Kim, Young Suk Yu, Dongha Kim, Se Won Park, Jinhyuk Bhin, Daehee Hwang, Ho Lee, Gou Young Koh, Sung Hee Baek
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/a4ea271d5fa347f9aabf818c7ba44cbe
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