Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

HIF-1α is a pivotal protein involved in angiogenesis and is known to be regulated posttranslationally. Here, the authors show that HIF-1α is methylated by Set7/9 methyltransferase, which reduces protein stability and contributes to reduced angiogenesis.

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Autores principales:	Yunho Kim, Hye Jin Nam, Junyeop Lee, Do Young Park, Chan Kim, Young Suk Yu, Dongha Kim, Se Won Park, Jinhyuk Bhin, Daehee Hwang, Ho Lee, Gou Young Koh, Sung Hee Baek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a4ea271d5fa347f9aabf818c7ba44cbe
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spelling	oai:doaj.org-article:a4ea271d5fa347f9aabf818c7ba44cbe2021-12-02T17:33:21ZMethylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis10.1038/ncomms103472041-1723https://doaj.org/article/a4ea271d5fa347f9aabf818c7ba44cbe2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10347https://doaj.org/toc/2041-1723HIF-1α is a pivotal protein involved in angiogenesis and is known to be regulated posttranslationally. Here, the authors show that HIF-1α is methylated by Set7/9 methyltransferase, which reduces protein stability and contributes to reduced angiogenesis.Yunho KimHye Jin NamJunyeop LeeDo Young ParkChan KimYoung Suk YuDongha KimSe Won ParkJinhyuk BhinDaehee HwangHo LeeGou Young KohSung Hee BaekNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yunho Kim Hye Jin Nam Junyeop Lee Do Young Park Chan Kim Young Suk Yu Dongha Kim Se Won Park Jinhyuk Bhin Daehee Hwang Ho Lee Gou Young Koh Sung Hee Baek Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
description	HIF-1α is a pivotal protein involved in angiogenesis and is known to be regulated posttranslationally. Here, the authors show that HIF-1α is methylated by Set7/9 methyltransferase, which reduces protein stability and contributes to reduced angiogenesis.
format	article
author	Yunho Kim Hye Jin Nam Junyeop Lee Do Young Park Chan Kim Young Suk Yu Dongha Kim Se Won Park Jinhyuk Bhin Daehee Hwang Ho Lee Gou Young Koh Sung Hee Baek
author_facet	Yunho Kim Hye Jin Nam Junyeop Lee Do Young Park Chan Kim Young Suk Yu Dongha Kim Se Won Park Jinhyuk Bhin Daehee Hwang Ho Lee Gou Young Koh Sung Hee Baek
author_sort	Yunho Kim
title	Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
title_short	Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
title_full	Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
title_fullStr	Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
title_full_unstemmed	Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
title_sort	methylation-dependent regulation of hif-1α stability restricts retinal and tumour angiogenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a4ea271d5fa347f9aabf818c7ba44cbe
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Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

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