Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis
HIF-1α is a pivotal protein involved in angiogenesis and is known to be regulated posttranslationally. Here, the authors show that HIF-1α is methylated by Set7/9 methyltransferase, which reduces protein stability and contributes to reduced angiogenesis.
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2016
|
| Subjects: | |
| Online Access: | https://doaj.org/article/a4ea271d5fa347f9aabf818c7ba44cbe |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|