Restoration of 5-methoxytryptophan protects against atherosclerotic chondrogenesis and calcification in ApoE −/− mice fed high fat diet
Abstract Background Toll-like receptor-2 (TLR2) promotes vascular smooth muscle cell (VSMC) transdifferentiation to chondrocytes and calcification in a p38 MAPK-dependent manner. Vascular 5-methoxytryptophan (5-MTP) is a newly identified factor with anti-inflammatory actions. As 5-MTP targets p38 MA...
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| Auteurs principaux: | , , , , |
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| Format: | article |
| Langue: | EN |
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BMC
2021
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/a55bba9b5f4e4c37833b595349e04928 |
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