Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals.

ADA is an enzyme implicated in purine metabolism, and is critical to ensure normal immune function. Its congenital deficit leads to severe combined immunodeficiency (SCID). ADA binding to adenosine receptors on dendritic cell surface enables T-cell costimulation through CD26 crosslinking, which enha...

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Autores principales: Víctor Casanova, Isaac Naval-Macabuhay, Marta Massanella, Marta Rodríguez-García, Julià Blanco, José M Gatell, Felipe García, Teresa Gallart, Carme Lluis, Josefa Mallol, Rafael Franco, Núria Climent, Peter J McCormick
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/a5b2016ec1294af0bcdc5275b1d538a6
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