Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi

Intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. Here the authors show that VEGF-C expression in specialized IntSCs is regulated by YAP/TAZ, and VEGF-C is responsible for maintaining lacteal integrity, thus influencing dietary fat drainage into lacteals.

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Autores principales:	Seon Pyo Hong, Myung Jin Yang, Hyunsoo Cho, Intae Park, Hosung Bae, Kibaek Choe, Sang Heon Suh, Ralf H. Adams, Kari Alitalo, Daesik Lim, Gou Young Koh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5ba88c8e1874761a4ed5a9319bf3ec3
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spelling	oai:doaj.org-article:a5ba88c8e1874761a4ed5a9319bf3ec32021-12-02T16:43:39ZDistinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi10.1038/s41467-020-17886-y2041-1723https://doaj.org/article/a5ba88c8e1874761a4ed5a9319bf3ec32020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17886-yhttps://doaj.org/toc/2041-1723Intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. Here the authors show that VEGF-C expression in specialized IntSCs is regulated by YAP/TAZ, and VEGF-C is responsible for maintaining lacteal integrity, thus influencing dietary fat drainage into lacteals.Seon Pyo HongMyung Jin YangHyunsoo ChoIntae ParkHosung BaeKibaek ChoeSang Heon SuhRalf H. AdamsKari AlitaloDaesik LimGou Young KohNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seon Pyo Hong Myung Jin Yang Hyunsoo Cho Intae Park Hosung Bae Kibaek Choe Sang Heon Suh Ralf H. Adams Kari Alitalo Daesik Lim Gou Young Koh Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
description	Intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. Here the authors show that VEGF-C expression in specialized IntSCs is regulated by YAP/TAZ, and VEGF-C is responsible for maintaining lacteal integrity, thus influencing dietary fat drainage into lacteals.
format	article
author	Seon Pyo Hong Myung Jin Yang Hyunsoo Cho Intae Park Hosung Bae Kibaek Choe Sang Heon Suh Ralf H. Adams Kari Alitalo Daesik Lim Gou Young Koh
author_facet	Seon Pyo Hong Myung Jin Yang Hyunsoo Cho Intae Park Hosung Bae Kibaek Choe Sang Heon Suh Ralf H. Adams Kari Alitalo Daesik Lim Gou Young Koh
author_sort	Seon Pyo Hong
title	Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
title_short	Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
title_full	Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
title_fullStr	Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
title_full_unstemmed	Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
title_sort	distinct fibroblast subsets regulate lacteal integrity through yap/taz-induced vegf-c in intestinal villi
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a5ba88c8e1874761a4ed5a9319bf3ec3
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Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi

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