Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi

Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi

Intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. Here the authors show that VEGF-C expression in specialized IntSCs is regulated by YAP/TAZ, and VEGF-C is responsible for maintaining lacteal integrity, thus influencing dietary fat drainage into lacteals.

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Bibliographic Details
Main Authors: Seon Pyo Hong, Myung Jin Yang, Hyunsoo Cho, Intae Park, Hosung Bae, Kibaek Choe, Sang Heon Suh, Ralf H. Adams, Kari Alitalo, Daesik Lim, Gou Young Koh
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/a5ba88c8e1874761a4ed5a9319bf3ec3
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https://doaj.org/article/a5ba88c8e1874761a4ed5a9319bf3ec3

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