Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia

Disease monitoring of chronic lymphocytic leukaemia (CLL) is a challenge. Here, the authors show that serial ctDNA analysis in 32 CLL patients allows monitoring of clonal dynamics over time, and identifies the emergence of genomic changes associated with Richter’s syndrome.

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Autores principales:	Paul Yeh, Tane Hunter, Devbarna Sinha, Sarah Ftouni, Elise Wallach, Damian Jiang, Yih-Chih Chan, Stephen Q. Wong, Maria Joao Silva, Ravikiran Vedururu, Kenneth Doig, Enid Lam, Gisela Mir Arnau, Timothy Semple, Meaghan Wall, Andjelija Zivanovic, Rishu Agarwal, Pasquale Petrone, Kate Jones, David Westerman, Piers Blombery, John F. Seymour, Anthony T. Papenfuss, Mark A. Dawson, Constantine S. Tam, Sarah-Jane Dawson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5d0115fb7e149b29d91aa033cf28281
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spelling	oai:doaj.org-article:a5d0115fb7e149b29d91aa033cf282812021-12-02T15:37:03ZCirculating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia10.1038/ncomms147562041-1723https://doaj.org/article/a5d0115fb7e149b29d91aa033cf282812017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14756https://doaj.org/toc/2041-1723Disease monitoring of chronic lymphocytic leukaemia (CLL) is a challenge. Here, the authors show that serial ctDNA analysis in 32 CLL patients allows monitoring of clonal dynamics over time, and identifies the emergence of genomic changes associated with Richter’s syndrome.Paul YehTane HunterDevbarna SinhaSarah FtouniElise WallachDamian JiangYih-Chih ChanStephen Q. WongMaria Joao SilvaRavikiran VedururuKenneth DoigEnid LamGisela Mir ArnauTimothy SempleMeaghan WallAndjelija ZivanovicRishu AgarwalPasquale PetroneKate JonesDavid WestermanPiers BlomberyJohn F. SeymourAnthony T. PapenfussMark A. DawsonConstantine S. TamSarah-Jane DawsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paul Yeh Tane Hunter Devbarna Sinha Sarah Ftouni Elise Wallach Damian Jiang Yih-Chih Chan Stephen Q. Wong Maria Joao Silva Ravikiran Vedururu Kenneth Doig Enid Lam Gisela Mir Arnau Timothy Semple Meaghan Wall Andjelija Zivanovic Rishu Agarwal Pasquale Petrone Kate Jones David Westerman Piers Blombery John F. Seymour Anthony T. Papenfuss Mark A. Dawson Constantine S. Tam Sarah-Jane Dawson Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia
description	Disease monitoring of chronic lymphocytic leukaemia (CLL) is a challenge. Here, the authors show that serial ctDNA analysis in 32 CLL patients allows monitoring of clonal dynamics over time, and identifies the emergence of genomic changes associated with Richter’s syndrome.
format	article
author	Paul Yeh Tane Hunter Devbarna Sinha Sarah Ftouni Elise Wallach Damian Jiang Yih-Chih Chan Stephen Q. Wong Maria Joao Silva Ravikiran Vedururu Kenneth Doig Enid Lam Gisela Mir Arnau Timothy Semple Meaghan Wall Andjelija Zivanovic Rishu Agarwal Pasquale Petrone Kate Jones David Westerman Piers Blombery John F. Seymour Anthony T. Papenfuss Mark A. Dawson Constantine S. Tam Sarah-Jane Dawson
author_facet	Paul Yeh Tane Hunter Devbarna Sinha Sarah Ftouni Elise Wallach Damian Jiang Yih-Chih Chan Stephen Q. Wong Maria Joao Silva Ravikiran Vedururu Kenneth Doig Enid Lam Gisela Mir Arnau Timothy Semple Meaghan Wall Andjelija Zivanovic Rishu Agarwal Pasquale Petrone Kate Jones David Westerman Piers Blombery John F. Seymour Anthony T. Papenfuss Mark A. Dawson Constantine S. Tam Sarah-Jane Dawson
author_sort	Paul Yeh
title	Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia
title_short	Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia
title_full	Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia
title_fullStr	Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia
title_full_unstemmed	Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia
title_sort	circulating tumour dna reflects treatment response and clonal evolution in chronic lymphocytic leukaemia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a5d0115fb7e149b29d91aa033cf28281
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Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia

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