CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data

The control of off-target activity is a challenge for adapting CRISPR to therapeutic use. Here the authors present CRISPECTOR, a software tool to detect, evaluate and quantify editing activity, including translocations, from NGS data.

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Autores principales:	Ido Amit, Ortal Iancu, Alona Levy-Jurgenson, Gavin Kurgan, Matthew S. McNeill, Garrett R. Rettig, Daniel Allen, Dor Breier, Nimrod Ben Haim, Yu Wang, Leon Anavy, Ayal Hendel, Zohar Yakhini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5eef4e669634506b9f9db24ef9fe0fe
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spelling	oai:doaj.org-article:a5eef4e669634506b9f9db24ef9fe0fe2021-12-02T15:00:49ZCRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data10.1038/s41467-021-22417-42041-1723https://doaj.org/article/a5eef4e669634506b9f9db24ef9fe0fe2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22417-4https://doaj.org/toc/2041-1723The control of off-target activity is a challenge for adapting CRISPR to therapeutic use. Here the authors present CRISPECTOR, a software tool to detect, evaluate and quantify editing activity, including translocations, from NGS data.Ido AmitOrtal IancuAlona Levy-JurgensonGavin KurganMatthew S. McNeillGarrett R. RettigDaniel AllenDor BreierNimrod Ben HaimYu WangLeon AnavyAyal HendelZohar YakhiniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ido Amit Ortal Iancu Alona Levy-Jurgenson Gavin Kurgan Matthew S. McNeill Garrett R. Rettig Daniel Allen Dor Breier Nimrod Ben Haim Yu Wang Leon Anavy Ayal Hendel Zohar Yakhini CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data
description	The control of off-target activity is a challenge for adapting CRISPR to therapeutic use. Here the authors present CRISPECTOR, a software tool to detect, evaluate and quantify editing activity, including translocations, from NGS data.
format	article
author	Ido Amit Ortal Iancu Alona Levy-Jurgenson Gavin Kurgan Matthew S. McNeill Garrett R. Rettig Daniel Allen Dor Breier Nimrod Ben Haim Yu Wang Leon Anavy Ayal Hendel Zohar Yakhini
author_facet	Ido Amit Ortal Iancu Alona Levy-Jurgenson Gavin Kurgan Matthew S. McNeill Garrett R. Rettig Daniel Allen Dor Breier Nimrod Ben Haim Yu Wang Leon Anavy Ayal Hendel Zohar Yakhini
author_sort	Ido Amit
title	CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data
title_short	CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data
title_full	CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data
title_fullStr	CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data
title_full_unstemmed	CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data
title_sort	crispector provides accurate estimation of genome editing translocation and off-target activity from comparative ngs data
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a5eef4e669634506b9f9db24ef9fe0fe
work_keys_str_mv	AT idoamit crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata AT ortaliancu crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata AT alonalevyjurgenson crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata AT gavinkurgan crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata AT matthewsmcneill crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata AT garrettrrettig crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata AT danielallen crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata AT dorbreier crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata AT nimrodbenhaim crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata AT yuwang crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata AT leonanavy crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata AT ayalhendel crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata AT zoharyakhini crispectorprovidesaccurateestimationofgenomeeditingtranslocationandofftargetactivityfromcomparativengsdata
_version_	1718389156521967616

CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data

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