Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

Hypoxia is known to promote tumor progression. Here, the authors evaluate hypoxic cells using a fate mapping approach and identify a distinct gene expression profile of cells exposed to intratumoral hypoxia and show that post-hypoxic tumor cells have an ROS-resistant phenotype enabling metastasis in...

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Autores principales: Inês Godet, Yu Jung Shin, Julia A. Ju, I Chae Ye, Guannan Wang, Daniele M. Gilkes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/a5f1f8419ccf4c21aec6a8ada0d7c50b
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