Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

Hypoxia is known to promote tumor progression. Here, the authors evaluate hypoxic cells using a fate mapping approach and identify a distinct gene expression profile of cells exposed to intratumoral hypoxia and show that post-hypoxic tumor cells have an ROS-resistant phenotype enabling metastasis in...

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Autores principales:	Inês Godet, Yu Jung Shin, Julia A. Ju, I Chae Ye, Guannan Wang, Daniele M. Gilkes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5f1f8419ccf4c21aec6a8ada0d7c50b
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spelling	oai:doaj.org-article:a5f1f8419ccf4c21aec6a8ada0d7c50b2021-12-02T15:36:00ZFate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis10.1038/s41467-019-12412-12041-1723https://doaj.org/article/a5f1f8419ccf4c21aec6a8ada0d7c50b2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12412-1https://doaj.org/toc/2041-1723Hypoxia is known to promote tumor progression. Here, the authors evaluate hypoxic cells using a fate mapping approach and identify a distinct gene expression profile of cells exposed to intratumoral hypoxia and show that post-hypoxic tumor cells have an ROS-resistant phenotype enabling metastasis in vivo.Inês GodetYu Jung ShinJulia A. JuI Chae YeGuannan WangDaniele M. GilkesNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Inês Godet Yu Jung Shin Julia A. Ju I Chae Ye Guannan Wang Daniele M. Gilkes Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
description	Hypoxia is known to promote tumor progression. Here, the authors evaluate hypoxic cells using a fate mapping approach and identify a distinct gene expression profile of cells exposed to intratumoral hypoxia and show that post-hypoxic tumor cells have an ROS-resistant phenotype enabling metastasis in vivo.
format	article
author	Inês Godet Yu Jung Shin Julia A. Ju I Chae Ye Guannan Wang Daniele M. Gilkes
author_facet	Inês Godet Yu Jung Shin Julia A. Ju I Chae Ye Guannan Wang Daniele M. Gilkes
author_sort	Inês Godet
title	Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
title_short	Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
title_full	Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
title_fullStr	Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
title_full_unstemmed	Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
title_sort	fate-mapping post-hypoxic tumor cells reveals a ros-resistant phenotype that promotes metastasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a5f1f8419ccf4c21aec6a8ada0d7c50b
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Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

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