Clonally stable Vκ allelic choice instructs Igκ repertoire

B cell development involves sequential rearrangement of the immunoglobulin chains, but fine control over the selection process remains a mystery. Here the authors show that individual alleles in pre-B cells are clonally unique and result from stochastic activation of V gene segments to induce optima...

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Autores principales: Rena Levin-Klein, Shira Fraenkel, Michal Lichtenstein, Louise S. Matheson, Osnat Bartok, Yuval Nevo, Sebastian Kadener, Anne E. Corcoran, Howard Cedar, Yehudit Bergman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/a60058be570b46449a317fcb6741376b
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