Clonally stable Vκ allelic choice instructs Igκ repertoire

B cell development involves sequential rearrangement of the immunoglobulin chains, but fine control over the selection process remains a mystery. Here the authors show that individual alleles in pre-B cells are clonally unique and result from stochastic activation of V gene segments to induce optima...

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Autores principales:	Rena Levin-Klein, Shira Fraenkel, Michal Lichtenstein, Louise S. Matheson, Osnat Bartok, Yuval Nevo, Sebastian Kadener, Anne E. Corcoran, Howard Cedar, Yehudit Bergman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a60058be570b46449a317fcb6741376b
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spelling	oai:doaj.org-article:a60058be570b46449a317fcb6741376b2021-12-02T14:42:41ZClonally stable Vκ allelic choice instructs Igκ repertoire10.1038/ncomms155752041-1723https://doaj.org/article/a60058be570b46449a317fcb6741376b2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15575https://doaj.org/toc/2041-1723B cell development involves sequential rearrangement of the immunoglobulin chains, but fine control over the selection process remains a mystery. Here the authors show that individual alleles in pre-B cells are clonally unique and result from stochastic activation of V gene segments to induce optimal generation of a diverse repertoire.Rena Levin-KleinShira FraenkelMichal LichtensteinLouise S. MathesonOsnat BartokYuval NevoSebastian KadenerAnne E. CorcoranHoward CedarYehudit BergmanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rena Levin-Klein Shira Fraenkel Michal Lichtenstein Louise S. Matheson Osnat Bartok Yuval Nevo Sebastian Kadener Anne E. Corcoran Howard Cedar Yehudit Bergman Clonally stable Vκ allelic choice instructs Igκ repertoire
description	B cell development involves sequential rearrangement of the immunoglobulin chains, but fine control over the selection process remains a mystery. Here the authors show that individual alleles in pre-B cells are clonally unique and result from stochastic activation of V gene segments to induce optimal generation of a diverse repertoire.
format	article
author	Rena Levin-Klein Shira Fraenkel Michal Lichtenstein Louise S. Matheson Osnat Bartok Yuval Nevo Sebastian Kadener Anne E. Corcoran Howard Cedar Yehudit Bergman
author_facet	Rena Levin-Klein Shira Fraenkel Michal Lichtenstein Louise S. Matheson Osnat Bartok Yuval Nevo Sebastian Kadener Anne E. Corcoran Howard Cedar Yehudit Bergman
author_sort	Rena Levin-Klein
title	Clonally stable Vκ allelic choice instructs Igκ repertoire
title_short	Clonally stable Vκ allelic choice instructs Igκ repertoire
title_full	Clonally stable Vκ allelic choice instructs Igκ repertoire
title_fullStr	Clonally stable Vκ allelic choice instructs Igκ repertoire
title_full_unstemmed	Clonally stable Vκ allelic choice instructs Igκ repertoire
title_sort	clonally stable vκ allelic choice instructs igκ repertoire
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a60058be570b46449a317fcb6741376b
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Clonally stable Vκ allelic choice instructs Igκ repertoire

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