Structural basis of homo- and heterotrimerization of collagen I

Heterotrimers of collagen I (two α1 chains, one α2 chain) are crucial for the normal function of multiple tissues and organs. Here the authors show the molecular basis of both homotrimerization (three α1 chains) and heterotrimerization of collagen I through specific intermolecular interactions.

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Autores principales:	Urvashi Sharma, Loïc Carrique, Sandrine Vadon-Le Goff, Natacha Mariano, Rainier-Numa Georges, Frederic Delolme, Peppi Koivunen, Johanna Myllyharju, Catherine Moali, Nushin Aghajari, David J. S. Hulmes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a60a8ed5f31b4d4886df090a13228cae
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spelling	oai:doaj.org-article:a60a8ed5f31b4d4886df090a13228cae2021-12-02T14:41:19ZStructural basis of homo- and heterotrimerization of collagen I10.1038/ncomms146712041-1723https://doaj.org/article/a60a8ed5f31b4d4886df090a13228cae2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14671https://doaj.org/toc/2041-1723Heterotrimers of collagen I (two α1 chains, one α2 chain) are crucial for the normal function of multiple tissues and organs. Here the authors show the molecular basis of both homotrimerization (three α1 chains) and heterotrimerization of collagen I through specific intermolecular interactions.Urvashi SharmaLoïc CarriqueSandrine Vadon-Le GoffNatacha MarianoRainier-Numa GeorgesFrederic DelolmePeppi KoivunenJohanna MyllyharjuCatherine MoaliNushin AghajariDavid J. S. HulmesNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Urvashi Sharma Loïc Carrique Sandrine Vadon-Le Goff Natacha Mariano Rainier-Numa Georges Frederic Delolme Peppi Koivunen Johanna Myllyharju Catherine Moali Nushin Aghajari David J. S. Hulmes Structural basis of homo- and heterotrimerization of collagen I
description	Heterotrimers of collagen I (two α1 chains, one α2 chain) are crucial for the normal function of multiple tissues and organs. Here the authors show the molecular basis of both homotrimerization (three α1 chains) and heterotrimerization of collagen I through specific intermolecular interactions.
format	article
author	Urvashi Sharma Loïc Carrique Sandrine Vadon-Le Goff Natacha Mariano Rainier-Numa Georges Frederic Delolme Peppi Koivunen Johanna Myllyharju Catherine Moali Nushin Aghajari David J. S. Hulmes
author_facet	Urvashi Sharma Loïc Carrique Sandrine Vadon-Le Goff Natacha Mariano Rainier-Numa Georges Frederic Delolme Peppi Koivunen Johanna Myllyharju Catherine Moali Nushin Aghajari David J. S. Hulmes
author_sort	Urvashi Sharma
title	Structural basis of homo- and heterotrimerization of collagen I
title_short	Structural basis of homo- and heterotrimerization of collagen I
title_full	Structural basis of homo- and heterotrimerization of collagen I
title_fullStr	Structural basis of homo- and heterotrimerization of collagen I
title_full_unstemmed	Structural basis of homo- and heterotrimerization of collagen I
title_sort	structural basis of homo- and heterotrimerization of collagen i
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a60a8ed5f31b4d4886df090a13228cae
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Structural basis of homo- and heterotrimerization of collagen I

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