Oncogenic KRAS Requires Complete Loss of BAP1 Function for Development of Murine Intrahepatic Cholangiocarcinoma

Oncogenic KRAS Requires Complete Loss of BAP1 Function for Development of Murine Intrahepatic Cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is a primary biliary malignancy that harbors a dismal prognosis. Oncogenic mutations of <i>KRAS</i> and loss-of-function mutations of <i>BRCA1-associated protein 1</i> (<i>BAP1</i>) have been identified as recurrent somatic al...

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Autores principales: Rebecca Marcus, Sammy Ferri-Borgogno, Abdel Hosein, Wai Chin Foo, Bidyut Ghosh, Jun Zhao, Kimal Rajapakshe, James Brugarolas, Anirban Maitra, Sonal Gupta
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
intrahepatic cholangiocarcinoma
mouse model
BAP1
KRAS
ferroptosis
SLC7A11
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/a62495aad21549c2a67f379c1a441774
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https://doaj.org/article/a62495aad21549c2a67f379c1a441774

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