Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation

Knowledge on how antibody responses have evolved is critical for the induction of protective immunity. Here the authors analyse, using high-throughput sequencing of both exon and intron regions, the mutation and lineage development of an HIV-neutralizing antibody to find an unexpected early emergenc...

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Autores principales:	Erik L. Johnson, Nicole A. Doria-Rose, Jason Gorman, Jinal N. Bhiman, Chaim A. Schramm, Ashley Q. Vu, William H. Law, Baoshan Zhang, Valerie Bekker, Salim S. Abdool Karim, Gregory C. Ippolito, Lynn Morris, Penny L. Moore, Peter D. Kwong, John R. Mascola, George Georgiou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a62bf922ef2c4169b0b995d4e2ae1f37
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spelling	oai:doaj.org-article:a62bf922ef2c4169b0b995d4e2ae1f372021-12-02T16:49:55ZSequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation10.1038/s41467-018-06424-62041-1723https://doaj.org/article/a62bf922ef2c4169b0b995d4e2ae1f372018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06424-6https://doaj.org/toc/2041-1723Knowledge on how antibody responses have evolved is critical for the induction of protective immunity. Here the authors analyse, using high-throughput sequencing of both exon and intron regions, the mutation and lineage development of an HIV-neutralizing antibody to find an unexpected early emergence of broadly neutralizing species.Erik L. JohnsonNicole A. Doria-RoseJason GormanJinal N. BhimanChaim A. SchrammAshley Q. VuWilliam H. LawBaoshan ZhangValerie BekkerSalim S. Abdool KarimGregory C. IppolitoLynn MorrisPenny L. MoorePeter D. KwongJohn R. MascolaGeorge GeorgiouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erik L. Johnson Nicole A. Doria-Rose Jason Gorman Jinal N. Bhiman Chaim A. Schramm Ashley Q. Vu William H. Law Baoshan Zhang Valerie Bekker Salim S. Abdool Karim Gregory C. Ippolito Lynn Morris Penny L. Moore Peter D. Kwong John R. Mascola George Georgiou Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation
description	Knowledge on how antibody responses have evolved is critical for the induction of protective immunity. Here the authors analyse, using high-throughput sequencing of both exon and intron regions, the mutation and lineage development of an HIV-neutralizing antibody to find an unexpected early emergence of broadly neutralizing species.
format	article
author	Erik L. Johnson Nicole A. Doria-Rose Jason Gorman Jinal N. Bhiman Chaim A. Schramm Ashley Q. Vu William H. Law Baoshan Zhang Valerie Bekker Salim S. Abdool Karim Gregory C. Ippolito Lynn Morris Penny L. Moore Peter D. Kwong John R. Mascola George Georgiou
author_facet	Erik L. Johnson Nicole A. Doria-Rose Jason Gorman Jinal N. Bhiman Chaim A. Schramm Ashley Q. Vu William H. Law Baoshan Zhang Valerie Bekker Salim S. Abdool Karim Gregory C. Ippolito Lynn Morris Penny L. Moore Peter D. Kwong John R. Mascola George Georgiou
author_sort	Erik L. Johnson
title	Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation
title_short	Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation
title_full	Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation
title_fullStr	Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation
title_full_unstemmed	Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation
title_sort	sequencing hiv-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a62bf922ef2c4169b0b995d4e2ae1f37
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Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation

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