Aberrant Intracellular pH Regulation Limiting Glyceraldehyde-3-Phosphate Dehydrogenase Activity in the Glucose-Sensitive Yeast <italic toggle="yes">tps1</italic>Δ Mutant

ABSTRACT Whereas the yeast Saccharomyces cerevisiae shows great preference for glucose as a carbon source, a deletion mutant in trehalose-6-phosphate synthase, tps1Δ, is highly sensitive to even a few millimolar glucose, which triggers apoptosis and cell death. Glucose addition to tps1Δ cells causes...

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Autores principales: Frederik Van Leemputte, Ward Vanthienen, Stefanie Wijnants, Griet Van Zeebroeck, Johan M. Thevelein
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
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Acceso en línea:https://doaj.org/article/a635266183c74eef89fb5533e010461d
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