Evaluation of mutation rates, mosaicism and off target mutations when injecting Cas9 mRNA or protein for genome editing of bovine embryos

Abstract The CRISPR/Cas9 genome editing tool has the potential to improve the livestock breeding industry by allowing for the introduction of desirable traits. Although an efficient and targeted tool, the CRISPR/Cas9 system can have some drawbacks, including off-target mutations and mosaicism, parti...

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Autores principales: Sadie L. Hennig, Joseph R. Owen, Jason C. Lin, Amy E. Young, Pablo J. Ross, Alison L. Van Eenennaam, James D. Murray
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a638503bf58644bba5b9de2748db09bb
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