Evaluation of mutation rates, mosaicism and off target mutations when injecting Cas9 mRNA or protein for genome editing of bovine embryos

Evaluation of mutation rates, mosaicism and off target mutations when injecting Cas9 mRNA or protein for genome editing of bovine embryos

Abstract The CRISPR/Cas9 genome editing tool has the potential to improve the livestock breeding industry by allowing for the introduction of desirable traits. Although an efficient and targeted tool, the CRISPR/Cas9 system can have some drawbacks, including off-target mutations and mosaicism, parti...

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Autores principales: Sadie L. Hennig, Joseph R. Owen, Jason C. Lin, Amy E. Young, Pablo J. Ross, Alison L. Van Eenennaam, James D. Murray
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/a638503bf58644bba5b9de2748db09bb
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