MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer

MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer

Summary: We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multiomics data and developed a biocomputational platform to construct a mathemati...

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Main Authors: ManSai Acón, Carsten Geiß, Jorge Torres-Calvo, Diana Bravo-Estupiñan, Guillermo Oviedo, Jorge L. Arias-Arias, Luis A. Rojas-Matey, Baez Edwin, Gloriana Vásquez-Vargas, Yendry Oses-Vargas, José Guevara-Coto, Andrés Segura-Castillo, Francisco Siles-Canales, Steve Quirós-Barrantes, Anne Régnier-Vigouroux, Pedro Mendes, Rodrigo Mora-Rodríguez
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
Bioinformatics
Mathematical biosciences
Systems biology
Science
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Online Access:https://doaj.org/article/a65d6bd5d804487198de0595ac10da3c
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https://doaj.org/article/a65d6bd5d804487198de0595ac10da3c

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