Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases

Bacterial two-component systems are composed of a sensor histidine kinase (HK) and an effector response regulator and upon signal detection, the HK autophosphorylates a conserved His residue. Here the authors structurally and functionally characterise two HKs, HK853–RR468 and EnvZ–OmpR, and find tha...

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Autores principales: Cristina Mideros-Mora, Laura Miguel-Romero, Alonso Felipe-Ruiz, Patricia Casino, Alberto Marina
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a680d0f7de9a49d3bb3359801876a0f3
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