On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

ABSTRACT Cas1 integrase is the key enzyme of the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptation module that mediates acquisition of spacers derived from foreign DNA by CRISPR arrays. In diverse bacteria, the cas1 gene is fused (or adjacent) to a gene encoding a reve...

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Bibliographic Details
Main Authors: Sukrit Silas, Kira S. Makarova, Sergey Shmakov, David Páez-Espino, Georg Mohr, Yi Liu, Michelle Davison, Simon Roux, Siddharth R. Krishnamurthy, Becky Xu Hua Fu, Loren L. Hansen, David Wang, Matthew B. Sullivan, Andrew Millard, Martha R. Clokie, Devaki Bhaya, Alan M. Lambowitz, Nikos C. Kyrpides, Eugene V. Koonin, Andrew Z. Fire
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
CRISPR
RNA spacer acquisition
cyanobacteria
deep sequencing
horizontal gene transfer
host-parasite relationship
Microbiology
QR1-502
Online Access:https://doaj.org/article/a69cf1b12c9e44f9b5265cbf1b3feb45
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