Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity

Abstract Gram-negative bacteria-derived lipopolysaccharides (LPS) are associated with various negative health effects. Whether diet is associated with LPS, is an understudied phenomenon. We investigated the association between diet and serum LPS activity in 668 individuals with type 1 diabetes in th...

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Autores principales:	Aila J Ahola, Mariann I. Lassenius, Carol Forsblom, Valma Harjutsalo, Markku Lehto, Per-Henrik Groop
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6a1ec4f4e374e3dbdcce0119f2d7cc0
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spelling	oai:doaj.org-article:a6a1ec4f4e374e3dbdcce0119f2d7cc02021-12-02T15:05:45ZDietary patterns reflecting healthy food choices are associated with lower serum LPS activity10.1038/s41598-017-06885-72045-2322https://doaj.org/article/a6a1ec4f4e374e3dbdcce0119f2d7cc02017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06885-7https://doaj.org/toc/2045-2322Abstract Gram-negative bacteria-derived lipopolysaccharides (LPS) are associated with various negative health effects. Whether diet is associated with LPS, is an understudied phenomenon. We investigated the association between diet and serum LPS activity in 668 individuals with type 1 diabetes in the FinnDiane Study. Serum LPS activity was determined using the Limulus Amoebocyte Lysate assay. Diet was assessed with a food frequency questionnaire (FFQ) section of a diet questionnaire and a food record. The food record was used to calculate energy, macronutrient, and fibre intake. In a multivariable model, energy, macronutrient, or fibre intake was not associated with the LPS activity. Using factor analysis, we identified seven dietary patterns from the FFQ data (“Sweet”, “Cheese”, “Fish”, “Healthy snack”, “Vegetable”, “Traditional”, and “Modern”). In a multivariable model, higher factor scores of the Fish, Healthy snack, and Modern patterns predicted lower LPS activity. The validity of the diet questionnaire was also investigated. The questionnaire showed reasonable relative validity against a 6-day food record. The two methods classified participants into the dietary patterns better than expected by chance. In conclusion, healthy dietary choices, such as consumption of fish, fresh vegetables, and fruits and berries may be associated with positive health outcomes by reducing systemic endotoxaemia.Aila J AholaMariann I. LasseniusCarol ForsblomValma HarjutsaloMarkku LehtoPer-Henrik GroopNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aila J Ahola Mariann I. Lassenius Carol Forsblom Valma Harjutsalo Markku Lehto Per-Henrik Groop Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity
description	Abstract Gram-negative bacteria-derived lipopolysaccharides (LPS) are associated with various negative health effects. Whether diet is associated with LPS, is an understudied phenomenon. We investigated the association between diet and serum LPS activity in 668 individuals with type 1 diabetes in the FinnDiane Study. Serum LPS activity was determined using the Limulus Amoebocyte Lysate assay. Diet was assessed with a food frequency questionnaire (FFQ) section of a diet questionnaire and a food record. The food record was used to calculate energy, macronutrient, and fibre intake. In a multivariable model, energy, macronutrient, or fibre intake was not associated with the LPS activity. Using factor analysis, we identified seven dietary patterns from the FFQ data (“Sweet”, “Cheese”, “Fish”, “Healthy snack”, “Vegetable”, “Traditional”, and “Modern”). In a multivariable model, higher factor scores of the Fish, Healthy snack, and Modern patterns predicted lower LPS activity. The validity of the diet questionnaire was also investigated. The questionnaire showed reasonable relative validity against a 6-day food record. The two methods classified participants into the dietary patterns better than expected by chance. In conclusion, healthy dietary choices, such as consumption of fish, fresh vegetables, and fruits and berries may be associated with positive health outcomes by reducing systemic endotoxaemia.
format	article
author	Aila J Ahola Mariann I. Lassenius Carol Forsblom Valma Harjutsalo Markku Lehto Per-Henrik Groop
author_facet	Aila J Ahola Mariann I. Lassenius Carol Forsblom Valma Harjutsalo Markku Lehto Per-Henrik Groop
author_sort	Aila J Ahola
title	Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity
title_short	Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity
title_full	Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity
title_fullStr	Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity
title_full_unstemmed	Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity
title_sort	dietary patterns reflecting healthy food choices are associated with lower serum lps activity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a6a1ec4f4e374e3dbdcce0119f2d7cc0
work_keys_str_mv	AT ailajahola dietarypatternsreflectinghealthyfoodchoicesareassociatedwithlowerserumlpsactivity AT mariannilassenius dietarypatternsreflectinghealthyfoodchoicesareassociatedwithlowerserumlpsactivity AT carolforsblom dietarypatternsreflectinghealthyfoodchoicesareassociatedwithlowerserumlpsactivity AT valmaharjutsalo dietarypatternsreflectinghealthyfoodchoicesareassociatedwithlowerserumlpsactivity AT markkulehto dietarypatternsreflectinghealthyfoodchoicesareassociatedwithlowerserumlpsactivity AT perhenrikgroop dietarypatternsreflectinghealthyfoodchoicesareassociatedwithlowerserumlpsactivity
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Dietary patterns reflecting healthy food choices are associated with lower serum LPS activity

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