Active DNA unwinding and transport by a membrane-adapted helicase nanopore

Active DNA unwinding and transport by a membrane-adapted helicase nanopore

Active translocation of DNA through nanopores usually needs enzyme assistance. Here authors present a nanopore derived from helicase E1 of bovine papillomavirus (BPV) which acts as a conductive pore embedded in lipid membrane to allow the translocation of ssDNA and unwinding of dsDNA.

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Auteurs principaux: Ke Sun, Changjian Zhao, Xiaojun Zeng, Yuejia Chen, Xin Jiang, Xianting Ding, Lu Gou, Haiyang Xie, Xinqiong Li, Xialin Zhang, Sheng Lin, Linqin Dou, Long Wei, Haofu Niu, Ming Zhang, Ruocen Tian, Erica Sawyer, Qingyue Yuan, Yuqin Huang, Piaopiao Chen, Chengjian Zhao, Cuisong Zhou, Binwu Ying, Bingyang Shi, Xiawei Wei, Ruotian Jiang, Lei Zhang, Guangwen Lu, Jia Geng
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/a6b935d4164446e5bff1e992c773483b
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Internet

https://doaj.org/article/a6b935d4164446e5bff1e992c773483b

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