Active DNA unwinding and transport by a membrane-adapted helicase nanopore
Active translocation of DNA through nanopores usually needs enzyme assistance. Here authors present a nanopore derived from helicase E1 of bovine papillomavirus (BPV) which acts as a conductive pore embedded in lipid membrane to allow the translocation of ssDNA and unwinding of dsDNA.
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Nature Portfolio
2019
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| Acceso en línea: | https://doaj.org/article/a6b935d4164446e5bff1e992c773483b |
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oai:doaj.org-article:a6b935d4164446e5bff1e992c773483b2021-12-02T15:35:32ZActive DNA unwinding and transport by a membrane-adapted helicase nanopore10.1038/s41467-019-13047-y2041-1723https://doaj.org/article/a6b935d4164446e5bff1e992c773483b2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13047-yhttps://doaj.org/toc/2041-1723Active translocation of DNA through nanopores usually needs enzyme assistance. Here authors present a nanopore derived from helicase E1 of bovine papillomavirus (BPV) which acts as a conductive pore embedded in lipid membrane to allow the translocation of ssDNA and unwinding of dsDNA.Ke SunChangjian ZhaoXiaojun ZengYuejia ChenXin JiangXianting DingLu GouHaiyang XieXinqiong LiXialin ZhangSheng LinLinqin DouLong WeiHaofu NiuMing ZhangRuocen TianErica SawyerQingyue YuanYuqin HuangPiaopiao ChenChengjian ZhaoCuisong ZhouBinwu YingBingyang ShiXiawei WeiRuotian JiangLei ZhangGuangwen LuJia GengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ke Sun Changjian Zhao Xiaojun Zeng Yuejia Chen Xin Jiang Xianting Ding Lu Gou Haiyang Xie Xinqiong Li Xialin Zhang Sheng Lin Linqin Dou Long Wei Haofu Niu Ming Zhang Ruocen Tian Erica Sawyer Qingyue Yuan Yuqin Huang Piaopiao Chen Chengjian Zhao Cuisong Zhou Binwu Ying Bingyang Shi Xiawei Wei Ruotian Jiang Lei Zhang Guangwen Lu Jia Geng Active DNA unwinding and transport by a membrane-adapted helicase nanopore |
| description |
Active translocation of DNA through nanopores usually needs enzyme assistance. Here authors present a nanopore derived from helicase E1 of bovine papillomavirus (BPV) which acts as a conductive pore embedded in lipid membrane to allow the translocation of ssDNA and unwinding of dsDNA. |
| format |
article |
| author |
Ke Sun Changjian Zhao Xiaojun Zeng Yuejia Chen Xin Jiang Xianting Ding Lu Gou Haiyang Xie Xinqiong Li Xialin Zhang Sheng Lin Linqin Dou Long Wei Haofu Niu Ming Zhang Ruocen Tian Erica Sawyer Qingyue Yuan Yuqin Huang Piaopiao Chen Chengjian Zhao Cuisong Zhou Binwu Ying Bingyang Shi Xiawei Wei Ruotian Jiang Lei Zhang Guangwen Lu Jia Geng |
| author_facet |
Ke Sun Changjian Zhao Xiaojun Zeng Yuejia Chen Xin Jiang Xianting Ding Lu Gou Haiyang Xie Xinqiong Li Xialin Zhang Sheng Lin Linqin Dou Long Wei Haofu Niu Ming Zhang Ruocen Tian Erica Sawyer Qingyue Yuan Yuqin Huang Piaopiao Chen Chengjian Zhao Cuisong Zhou Binwu Ying Bingyang Shi Xiawei Wei Ruotian Jiang Lei Zhang Guangwen Lu Jia Geng |
| author_sort |
Ke Sun |
| title |
Active DNA unwinding and transport by a membrane-adapted helicase nanopore |
| title_short |
Active DNA unwinding and transport by a membrane-adapted helicase nanopore |
| title_full |
Active DNA unwinding and transport by a membrane-adapted helicase nanopore |
| title_fullStr |
Active DNA unwinding and transport by a membrane-adapted helicase nanopore |
| title_full_unstemmed |
Active DNA unwinding and transport by a membrane-adapted helicase nanopore |
| title_sort |
active dna unwinding and transport by a membrane-adapted helicase nanopore |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/a6b935d4164446e5bff1e992c773483b |
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