Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo

Photocaged inositol-pyrophosphates offer a tool to study cellular signalling, but their challenging synthesis has precluded any biological studies so far. Here, the authors report the synthesis and cellular delivery of a photocaged analogue, and show that it mediates protein translocation in cellulo...

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Autores principales:	Igor Pavlovic, Divyeshsinh T. Thakor, Jessica R. Vargas, Colin J. McKinlay, Sebastian Hauke, Philipp Anstaett, Rafael C. Camuña, Laurent Bigler, Gilles Gasser, Carsten Schultz, Paul A. Wender, Henning J. Jessen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6bac542d07b431a964d07a618a8a4d6
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spelling	oai:doaj.org-article:a6bac542d07b431a964d07a618a8a4d62021-12-02T15:34:52ZCellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo10.1038/ncomms106222041-1723https://doaj.org/article/a6bac542d07b431a964d07a618a8a4d62016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10622https://doaj.org/toc/2041-1723Photocaged inositol-pyrophosphates offer a tool to study cellular signalling, but their challenging synthesis has precluded any biological studies so far. Here, the authors report the synthesis and cellular delivery of a photocaged analogue, and show that it mediates protein translocation in cellulo.Igor PavlovicDivyeshsinh T. ThakorJessica R. VargasColin J. McKinlaySebastian HaukePhilipp AnstaettRafael C. CamuñaLaurent BiglerGilles GasserCarsten SchultzPaul A. WenderHenning J. JessenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Igor Pavlovic Divyeshsinh T. Thakor Jessica R. Vargas Colin J. McKinlay Sebastian Hauke Philipp Anstaett Rafael C. Camuña Laurent Bigler Gilles Gasser Carsten Schultz Paul A. Wender Henning J. Jessen Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo
description	Photocaged inositol-pyrophosphates offer a tool to study cellular signalling, but their challenging synthesis has precluded any biological studies so far. Here, the authors report the synthesis and cellular delivery of a photocaged analogue, and show that it mediates protein translocation in cellulo.
format	article
author	Igor Pavlovic Divyeshsinh T. Thakor Jessica R. Vargas Colin J. McKinlay Sebastian Hauke Philipp Anstaett Rafael C. Camuña Laurent Bigler Gilles Gasser Carsten Schultz Paul A. Wender Henning J. Jessen
author_facet	Igor Pavlovic Divyeshsinh T. Thakor Jessica R. Vargas Colin J. McKinlay Sebastian Hauke Philipp Anstaett Rafael C. Camuña Laurent Bigler Gilles Gasser Carsten Schultz Paul A. Wender Henning J. Jessen
author_sort	Igor Pavlovic
title	Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo
title_short	Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo
title_full	Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo
title_fullStr	Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo
title_full_unstemmed	Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo
title_sort	cellular delivery and photochemical release of a caged inositol-pyrophosphate induces ph-domain translocation in cellulo
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a6bac542d07b431a964d07a618a8a4d6
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Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo

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