A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell

Artificial enzymes can be used to elicit reactions in cells. Here, the authors developed such an artificial catalyst combined with a genetic switch, and showed that it was readily taken up by human cells and able to kick off a reaction cascade resulting in the biosynthesis of the desired product.

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Autores principales:	Yasunori Okamoto, Ryosuke Kojima, Fabian Schwizer, Eline Bartolami, Tillmann Heinisch, Stefan Matile, Martin Fussenegger, Thomas R. Ward
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6bc18d7dfce4b7480d201ebe6f6f857
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spelling	oai:doaj.org-article:a6bc18d7dfce4b7480d201ebe6f6f8572021-12-02T17:31:13ZA cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell10.1038/s41467-018-04440-02041-1723https://doaj.org/article/a6bc18d7dfce4b7480d201ebe6f6f8572018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04440-0https://doaj.org/toc/2041-1723Artificial enzymes can be used to elicit reactions in cells. Here, the authors developed such an artificial catalyst combined with a genetic switch, and showed that it was readily taken up by human cells and able to kick off a reaction cascade resulting in the biosynthesis of the desired product.Yasunori OkamotoRyosuke KojimaFabian SchwizerEline BartolamiTillmann HeinischStefan MatileMartin FusseneggerThomas R. WardNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yasunori Okamoto Ryosuke Kojima Fabian Schwizer Eline Bartolami Tillmann Heinisch Stefan Matile Martin Fussenegger Thomas R. Ward A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell
description	Artificial enzymes can be used to elicit reactions in cells. Here, the authors developed such an artificial catalyst combined with a genetic switch, and showed that it was readily taken up by human cells and able to kick off a reaction cascade resulting in the biosynthesis of the desired product.
format	article
author	Yasunori Okamoto Ryosuke Kojima Fabian Schwizer Eline Bartolami Tillmann Heinisch Stefan Matile Martin Fussenegger Thomas R. Ward
author_facet	Yasunori Okamoto Ryosuke Kojima Fabian Schwizer Eline Bartolami Tillmann Heinisch Stefan Matile Martin Fussenegger Thomas R. Ward
author_sort	Yasunori Okamoto
title	A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell
title_short	A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell
title_full	A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell
title_fullStr	A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell
title_full_unstemmed	A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell
title_sort	cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a6bc18d7dfce4b7480d201ebe6f6f857
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A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell

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