Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials

DNA nanopores can span lipid bilayers but how they interact with lipids is not known. Here the authors establish at single-molecule level the insertion mechanism and show that DNA nanopores can locally cluster and remodel membranes, and stabilize autonomously formed lipid nanotubes.

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Autores principales:	Oliver Birkholz, Jonathan R. Burns, Christian P. Richter, Olympia E. Psathaki, Stefan Howorka, Jacob Piehler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a70c150306da4a7bb1f6a39c57387551
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spelling	oai:doaj.org-article:a70c150306da4a7bb1f6a39c573875512021-12-02T14:39:26ZMulti-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials10.1038/s41467-018-02905-w2041-1723https://doaj.org/article/a70c150306da4a7bb1f6a39c573875512018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02905-whttps://doaj.org/toc/2041-1723DNA nanopores can span lipid bilayers but how they interact with lipids is not known. Here the authors establish at single-molecule level the insertion mechanism and show that DNA nanopores can locally cluster and remodel membranes, and stabilize autonomously formed lipid nanotubes.Oliver BirkholzJonathan R. BurnsChristian P. RichterOlympia E. PsathakiStefan HoworkaJacob PiehlerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Oliver Birkholz Jonathan R. Burns Christian P. Richter Olympia E. Psathaki Stefan Howorka Jacob Piehler Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials
description	DNA nanopores can span lipid bilayers but how they interact with lipids is not known. Here the authors establish at single-molecule level the insertion mechanism and show that DNA nanopores can locally cluster and remodel membranes, and stabilize autonomously formed lipid nanotubes.
format	article
author	Oliver Birkholz Jonathan R. Burns Christian P. Richter Olympia E. Psathaki Stefan Howorka Jacob Piehler
author_facet	Oliver Birkholz Jonathan R. Burns Christian P. Richter Olympia E. Psathaki Stefan Howorka Jacob Piehler
author_sort	Oliver Birkholz
title	Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials
title_short	Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials
title_full	Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials
title_fullStr	Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials
title_full_unstemmed	Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials
title_sort	multi-functional dna nanostructures that puncture and remodel lipid membranes into hybrid materials
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a70c150306da4a7bb1f6a39c57387551
work_keys_str_mv	AT oliverbirkholz multifunctionaldnananostructuresthatpunctureandremodellipidmembranesintohybridmaterials AT jonathanrburns multifunctionaldnananostructuresthatpunctureandremodellipidmembranesintohybridmaterials AT christianprichter multifunctionaldnananostructuresthatpunctureandremodellipidmembranesintohybridmaterials AT olympiaepsathaki multifunctionaldnananostructuresthatpunctureandremodellipidmembranesintohybridmaterials AT stefanhoworka multifunctionaldnananostructuresthatpunctureandremodellipidmembranesintohybridmaterials AT jacobpiehler multifunctionaldnananostructuresthatpunctureandremodellipidmembranesintohybridmaterials
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Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials

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