Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation

It is known that Purkinje cell PKC-dependent depression is involved in the stabilization of self-motion based hippocampal representation. Here the authors describe decreased stability of hippocampal place cells based on allocentric cues in mice lacking Purkinje cell PP2B-dependent potentiation.

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Autores principales: Julie Marie Lefort, Jean Vincent, Lucille Tallot, Frédéric Jarlier, Chris Innocentius De Zeeuw, Laure Rondi-Reig, Christelle Rochefort
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/a721c79a49814e708b07b51a199488f5
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