Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin

The cofilin family proteins are actin disassembly factors but the disassembly mechanism is poorly understood. Here authors show that cyclase-associated-protein (CAP) works in synergy with cofilin to accelerate actin filament depolymerization by nearly 100-fold and reveal how CAP destabilizes the int...

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Autores principales:	Tommi Kotila, Hugo Wioland, Giray Enkavi, Konstantin Kogan, Ilpo Vattulainen, Antoine Jégou, Guillaume Romet-Lemonne, Pekka Lappalainen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a7e7c8a65f604e56a1377651d6ef54c8
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spelling	oai:doaj.org-article:a7e7c8a65f604e56a1377651d6ef54c82021-12-02T16:58:28ZMechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin10.1038/s41467-019-13213-22041-1723https://doaj.org/article/a7e7c8a65f604e56a1377651d6ef54c82019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13213-2https://doaj.org/toc/2041-1723The cofilin family proteins are actin disassembly factors but the disassembly mechanism is poorly understood. Here authors show that cyclase-associated-protein (CAP) works in synergy with cofilin to accelerate actin filament depolymerization by nearly 100-fold and reveal how CAP destabilizes the interface between terminal actin subunits.Tommi KotilaHugo WiolandGiray EnkaviKonstantin KoganIlpo VattulainenAntoine JégouGuillaume Romet-LemonnePekka LappalainenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tommi Kotila Hugo Wioland Giray Enkavi Konstantin Kogan Ilpo Vattulainen Antoine Jégou Guillaume Romet-Lemonne Pekka Lappalainen Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin
description	The cofilin family proteins are actin disassembly factors but the disassembly mechanism is poorly understood. Here authors show that cyclase-associated-protein (CAP) works in synergy with cofilin to accelerate actin filament depolymerization by nearly 100-fold and reveal how CAP destabilizes the interface between terminal actin subunits.
format	article
author	Tommi Kotila Hugo Wioland Giray Enkavi Konstantin Kogan Ilpo Vattulainen Antoine Jégou Guillaume Romet-Lemonne Pekka Lappalainen
author_facet	Tommi Kotila Hugo Wioland Giray Enkavi Konstantin Kogan Ilpo Vattulainen Antoine Jégou Guillaume Romet-Lemonne Pekka Lappalainen
author_sort	Tommi Kotila
title	Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin
title_short	Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin
title_full	Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin
title_fullStr	Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin
title_full_unstemmed	Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin
title_sort	mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a7e7c8a65f604e56a1377651d6ef54c8
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Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin

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