Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation

A desired product cannot be obtained at higher concentration than its equilibrium concentration when isomerases are used for biotransformation. Here, the authors engineer in vivo oxidoreductive reactions in yeast to overcome the equilibrium limitation of in vitro isomerases-based tagatose production...

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Autores principales:	Jing-Jing Liu, Guo-Chang Zhang, Suryang Kwak, Eun Joong Oh, Eun Ju Yun, Kulika Chomvong, Jamie H. D. Cate, Yong-Su Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a7eb7182bd4e490ca187e05c77980ea5
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spelling	oai:doaj.org-article:a7eb7182bd4e490ca187e05c77980ea52021-12-02T15:35:27ZOvercoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation10.1038/s41467-019-09288-62041-1723https://doaj.org/article/a7eb7182bd4e490ca187e05c77980ea52019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09288-6https://doaj.org/toc/2041-1723A desired product cannot be obtained at higher concentration than its equilibrium concentration when isomerases are used for biotransformation. Here, the authors engineer in vivo oxidoreductive reactions in yeast to overcome the equilibrium limitation of in vitro isomerases-based tagatose production.Jing-Jing LiuGuo-Chang ZhangSuryang KwakEun Joong OhEun Ju YunKulika ChomvongJamie H. D. CateYong-Su JinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jing-Jing Liu Guo-Chang Zhang Suryang Kwak Eun Joong Oh Eun Ju Yun Kulika Chomvong Jamie H. D. Cate Yong-Su Jin Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation
description	A desired product cannot be obtained at higher concentration than its equilibrium concentration when isomerases are used for biotransformation. Here, the authors engineer in vivo oxidoreductive reactions in yeast to overcome the equilibrium limitation of in vitro isomerases-based tagatose production.
format	article
author	Jing-Jing Liu Guo-Chang Zhang Suryang Kwak Eun Joong Oh Eun Ju Yun Kulika Chomvong Jamie H. D. Cate Yong-Su Jin
author_facet	Jing-Jing Liu Guo-Chang Zhang Suryang Kwak Eun Joong Oh Eun Ju Yun Kulika Chomvong Jamie H. D. Cate Yong-Su Jin
author_sort	Jing-Jing Liu
title	Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation
title_short	Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation
title_full	Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation
title_fullStr	Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation
title_full_unstemmed	Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation
title_sort	overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a7eb7182bd4e490ca187e05c77980ea5
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Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation

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