Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide

Human leukocyte antigen (HLA) presents peptides to activate T cells, but many aspects in the T cell receptor (TCR)/HLA interaction remain unclear. Here the authors show, via structural data, that two TCRs differentially recognize the same tumour peptide/HLA complex and induce contrasting conformatio...

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Autores principales:	Kok Fei Chan, Benjamin S. Gully, Stephanie Gras, Dennis X. Beringer, Lars Kjer-Nielsen, Jonathan Cebon, James McCluskey, Weisan Chen, Jamie Rossjohn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a7ed25c4fcb740c1b5d4980f12c82203
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spelling	oai:doaj.org-article:a7ed25c4fcb740c1b5d4980f12c822032021-12-02T15:34:19ZDivergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide10.1038/s41467-018-03321-w2041-1723https://doaj.org/article/a7ed25c4fcb740c1b5d4980f12c822032018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03321-whttps://doaj.org/toc/2041-1723Human leukocyte antigen (HLA) presents peptides to activate T cells, but many aspects in the T cell receptor (TCR)/HLA interaction remain unclear. Here the authors show, via structural data, that two TCRs differentially recognize the same tumour peptide/HLA complex and induce contrasting conformation changes of the peptide.Kok Fei ChanBenjamin S. GullyStephanie GrasDennis X. BeringerLars Kjer-NielsenJonathan CebonJames McCluskeyWeisan ChenJamie RossjohnNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kok Fei Chan Benjamin S. Gully Stephanie Gras Dennis X. Beringer Lars Kjer-Nielsen Jonathan Cebon James McCluskey Weisan Chen Jamie Rossjohn Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide
description	Human leukocyte antigen (HLA) presents peptides to activate T cells, but many aspects in the T cell receptor (TCR)/HLA interaction remain unclear. Here the authors show, via structural data, that two TCRs differentially recognize the same tumour peptide/HLA complex and induce contrasting conformation changes of the peptide.
format	article
author	Kok Fei Chan Benjamin S. Gully Stephanie Gras Dennis X. Beringer Lars Kjer-Nielsen Jonathan Cebon James McCluskey Weisan Chen Jamie Rossjohn
author_facet	Kok Fei Chan Benjamin S. Gully Stephanie Gras Dennis X. Beringer Lars Kjer-Nielsen Jonathan Cebon James McCluskey Weisan Chen Jamie Rossjohn
author_sort	Kok Fei Chan
title	Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide
title_short	Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide
title_full	Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide
title_fullStr	Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide
title_full_unstemmed	Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide
title_sort	divergent t-cell receptor recognition modes of a hla-i restricted extended tumour-associated peptide
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a7ed25c4fcb740c1b5d4980f12c82203
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Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide

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