ERα-independent NRF2-mediated immunoregulatory activity of tamoxifen

ERα-independent NRF2-mediated immunoregulatory activity of tamoxifen

ABSTRACT: Sex differences in immune-mediated diseases are linked to the activity of estrogens on innate immunity cells, including macrophages. Tamoxifen (TAM) is a selective estrogen receptor modulator (SERM) used in estrogen receptor-alpha (ERα)-dependent breast cancers and off-target indications s...

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Main Authors: Giovanna Pepe, Chiara Sfogliarini, Loris Rizzello, Giuseppe Battaglia, Christian Pinna, Gianenrico Rovati, Paolo Ciana, Electra Brunialti, Federica Mornata, Adriana Maggi, Massimo Locati, Elisabetta Vegeto
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
tamoxifen
macrophage
inflammation
drug repurposing
Nrf2
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/a7edf7f586f44f0282507cf6c6d73aa5
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https://doaj.org/article/a7edf7f586f44f0282507cf6c6d73aa5

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