High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis.

The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a highly active endocytosis and recycling of the surface...

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Autores principales: Benoît Stijlemans, Guy Caljon, Senthil Kumar A Natesan, Dirk Saerens, Katja Conrath, David Pérez-Morga, Jeremy N Skepper, Alexandros Nikolaou, Lea Brys, Etienne Pays, Stefan Magez, Mark C Field, Patrick De Baetselier, Serge Muyldermans
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/a7f47e4a605e405ca7807a71666c3a46
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