Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target

Attempts to image activated macrophages in vivo have been hampered by selectivity and delivery problems. Here the authors develop a small molecule fluorescent probe specific to activated M1 and M2 macrophages, identify the orphan receptor Slc18b1/SLC18B1 as the mechanism of uptake, and use it to ima...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sung-Jin Park, Beomsue Kim, Sejong Choi, Sivaraman Balasubramaniam, Sung-Chan Lee, Jung Yeol Lee, Heon Seok Kim, Jun-Young Kim, Jong-Jin Kim, Yong-An Lee, Nam-Young Kang, Jin-Soo Kim, Young-Tae Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a80a5a7ec76b4b3aaca86bee713b6628
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a80a5a7ec76b4b3aaca86bee713b6628
record_format	dspace
spelling	oai:doaj.org-article:a80a5a7ec76b4b3aaca86bee713b66282021-12-02T17:02:17ZImaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target10.1038/s41467-019-08990-92041-1723https://doaj.org/article/a80a5a7ec76b4b3aaca86bee713b66282019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08990-9https://doaj.org/toc/2041-1723Attempts to image activated macrophages in vivo have been hampered by selectivity and delivery problems. Here the authors develop a small molecule fluorescent probe specific to activated M1 and M2 macrophages, identify the orphan receptor Slc18b1/SLC18B1 as the mechanism of uptake, and use it to image atherosclerosis in mice.Sung-Jin ParkBeomsue KimSejong ChoiSivaraman BalasubramaniamSung-Chan LeeJung Yeol LeeHeon Seok KimJun-Young KimJong-Jin KimYong-An LeeNam-Young KangJin-Soo KimYoung-Tae ChangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sung-Jin Park Beomsue Kim Sejong Choi Sivaraman Balasubramaniam Sung-Chan Lee Jung Yeol Lee Heon Seok Kim Jun-Young Kim Jong-Jin Kim Yong-An Lee Nam-Young Kang Jin-Soo Kim Young-Tae Chang Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target
description	Attempts to image activated macrophages in vivo have been hampered by selectivity and delivery problems. Here the authors develop a small molecule fluorescent probe specific to activated M1 and M2 macrophages, identify the orphan receptor Slc18b1/SLC18B1 as the mechanism of uptake, and use it to image atherosclerosis in mice.
format	article
author	Sung-Jin Park Beomsue Kim Sejong Choi Sivaraman Balasubramaniam Sung-Chan Lee Jung Yeol Lee Heon Seok Kim Jun-Young Kim Jong-Jin Kim Yong-An Lee Nam-Young Kang Jin-Soo Kim Young-Tae Chang
author_facet	Sung-Jin Park Beomsue Kim Sejong Choi Sivaraman Balasubramaniam Sung-Chan Lee Jung Yeol Lee Heon Seok Kim Jun-Young Kim Jong-Jin Kim Yong-An Lee Nam-Young Kang Jin-Soo Kim Young-Tae Chang
author_sort	Sung-Jin Park
title	Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target
title_short	Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target
title_full	Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target
title_fullStr	Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target
title_full_unstemmed	Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target
title_sort	imaging inflammation using an activated macrophage probe with slc18b1 as the activation-selective gating target
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a80a5a7ec76b4b3aaca86bee713b6628
work_keys_str_mv	AT sungjinpark imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget AT beomsuekim imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget AT sejongchoi imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget AT sivaramanbalasubramaniam imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget AT sungchanlee imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget AT jungyeollee imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget AT heonseokkim imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget AT junyoungkim imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget AT jongjinkim imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget AT yonganlee imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget AT namyoungkang imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget AT jinsookim imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget AT youngtaechang imaginginflammationusinganactivatedmacrophageprobewithslc18b1astheactivationselectivegatingtarget
_version_	1718381925733761024

Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target

Ejemplares similares