Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target

Attempts to image activated macrophages in vivo have been hampered by selectivity and delivery problems. Here the authors develop a small molecule fluorescent probe specific to activated M1 and M2 macrophages, identify the orphan receptor Slc18b1/SLC18B1 as the mechanism of uptake, and use it to ima...

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Autores principales: Sung-Jin Park, Beomsue Kim, Sejong Choi, Sivaraman Balasubramaniam, Sung-Chan Lee, Jung Yeol Lee, Heon Seok Kim, Jun-Young Kim, Jong-Jin Kim, Yong-An Lee, Nam-Young Kang, Jin-Soo Kim, Young-Tae Chang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/a80a5a7ec76b4b3aaca86bee713b6628
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