TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth

Acetylation of microtubules (MT) confers mechanical stability necessary for numerous cellular functions but its regulation is unclear. Here the authors show that the MT acetyltransferase αTAT1 is regulated by TGF-β-activated kinase 1 implicating TGF-β signaling in MT-related functions and disease....

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Autores principales: Nirav Shah, Sanjay Kumar, Naveed Zaman, Christopher C. Pan, Jeffrey C. Bloodworth, Wei Lei, John M. Streicher, Nadine Hempel, Karthikeyan Mythreye, Nam Y. Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/a82d270420fc4d0b91e4bda9d9eca3d2
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