TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth

Acetylation of microtubules (MT) confers mechanical stability necessary for numerous cellular functions but its regulation is unclear. Here the authors show that the MT acetyltransferase αTAT1 is regulated by TGF-β-activated kinase 1 implicating TGF-β signaling in MT-related functions and disease....

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Autores principales:	Nirav Shah, Sanjay Kumar, Naveed Zaman, Christopher C. Pan, Jeffrey C. Bloodworth, Wei Lei, John M. Streicher, Nadine Hempel, Karthikeyan Mythreye, Nam Y. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a82d270420fc4d0b91e4bda9d9eca3d2
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spelling	oai:doaj.org-article:a82d270420fc4d0b91e4bda9d9eca3d22021-12-02T16:49:20ZTAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth10.1038/s41467-018-04121-y2041-1723https://doaj.org/article/a82d270420fc4d0b91e4bda9d9eca3d22018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04121-yhttps://doaj.org/toc/2041-1723Acetylation of microtubules (MT) confers mechanical stability necessary for numerous cellular functions but its regulation is unclear. Here the authors show that the MT acetyltransferase αTAT1 is regulated by TGF-β-activated kinase 1 implicating TGF-β signaling in MT-related functions and disease.Nirav ShahSanjay KumarNaveed ZamanChristopher C. PanJeffrey C. BloodworthWei LeiJohn M. StreicherNadine HempelKarthikeyan MythreyeNam Y. LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nirav Shah Sanjay Kumar Naveed Zaman Christopher C. Pan Jeffrey C. Bloodworth Wei Lei John M. Streicher Nadine Hempel Karthikeyan Mythreye Nam Y. Lee TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth
description	Acetylation of microtubules (MT) confers mechanical stability necessary for numerous cellular functions but its regulation is unclear. Here the authors show that the MT acetyltransferase αTAT1 is regulated by TGF-β-activated kinase 1 implicating TGF-β signaling in MT-related functions and disease.
format	article
author	Nirav Shah Sanjay Kumar Naveed Zaman Christopher C. Pan Jeffrey C. Bloodworth Wei Lei John M. Streicher Nadine Hempel Karthikeyan Mythreye Nam Y. Lee
author_facet	Nirav Shah Sanjay Kumar Naveed Zaman Christopher C. Pan Jeffrey C. Bloodworth Wei Lei John M. Streicher Nadine Hempel Karthikeyan Mythreye Nam Y. Lee
author_sort	Nirav Shah
title	TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth
title_short	TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth
title_full	TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth
title_fullStr	TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth
title_full_unstemmed	TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth
title_sort	tak1 activation of alpha-tat1 and microtubule hyperacetylation control akt signaling and cell growth
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a82d270420fc4d0b91e4bda9d9eca3d2
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TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth

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