Synergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude

Cellular actin networks can be rapidly disassembled and remodeled in a few seconds, yet in vitro actin filaments depolymerize over minutes. Here the authors show that Cyclase-associated protein (CAP) and Cofilin synergize to processively depolymerize actin filament pointed ends 330-fold faster than...

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Autores principales:	Shashank Shekhar, Johnson Chung, Jane Kondev, Jeff Gelles, Bruce L. Goode
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a85eeae229464d918654826b7dd93a43
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spelling	oai:doaj.org-article:a85eeae229464d918654826b7dd93a432021-12-02T16:57:43ZSynergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude10.1038/s41467-019-13268-12041-1723https://doaj.org/article/a85eeae229464d918654826b7dd93a432019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13268-1https://doaj.org/toc/2041-1723Cellular actin networks can be rapidly disassembled and remodeled in a few seconds, yet in vitro actin filaments depolymerize over minutes. Here the authors show that Cyclase-associated protein (CAP) and Cofilin synergize to processively depolymerize actin filament pointed ends 330-fold faster than spontaneous depolymerization.Shashank ShekharJohnson ChungJane KondevJeff GellesBruce L. GoodeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shashank Shekhar Johnson Chung Jane Kondev Jeff Gelles Bruce L. Goode Synergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude
description	Cellular actin networks can be rapidly disassembled and remodeled in a few seconds, yet in vitro actin filaments depolymerize over minutes. Here the authors show that Cyclase-associated protein (CAP) and Cofilin synergize to processively depolymerize actin filament pointed ends 330-fold faster than spontaneous depolymerization.
format	article
author	Shashank Shekhar Johnson Chung Jane Kondev Jeff Gelles Bruce L. Goode
author_facet	Shashank Shekhar Johnson Chung Jane Kondev Jeff Gelles Bruce L. Goode
author_sort	Shashank Shekhar
title	Synergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude
title_short	Synergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude
title_full	Synergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude
title_fullStr	Synergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude
title_full_unstemmed	Synergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude
title_sort	synergy between cyclase-associated protein and cofilin accelerates actin filament depolymerization by two orders of magnitude
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a85eeae229464d918654826b7dd93a43
work_keys_str_mv	AT shashankshekhar synergybetweencyclaseassociatedproteinandcofilinacceleratesactinfilamentdepolymerizationbytwoordersofmagnitude AT johnsonchung synergybetweencyclaseassociatedproteinandcofilinacceleratesactinfilamentdepolymerizationbytwoordersofmagnitude AT janekondev synergybetweencyclaseassociatedproteinandcofilinacceleratesactinfilamentdepolymerizationbytwoordersofmagnitude AT jeffgelles synergybetweencyclaseassociatedproteinandcofilinacceleratesactinfilamentdepolymerizationbytwoordersofmagnitude AT brucelgoode synergybetweencyclaseassociatedproteinandcofilinacceleratesactinfilamentdepolymerizationbytwoordersofmagnitude
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Synergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude

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