Synergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude

Cellular actin networks can be rapidly disassembled and remodeled in a few seconds, yet in vitro actin filaments depolymerize over minutes. Here the authors show that Cyclase-associated protein (CAP) and Cofilin synergize to processively depolymerize actin filament pointed ends 330-fold faster than...

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Bibliographic Details
Main Authors: Shashank Shekhar, Johnson Chung, Jane Kondev, Jeff Gelles, Bruce L. Goode
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/a85eeae229464d918654826b7dd93a43
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