Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID

CRISPR-guided cytidine deaminases, including BE3 (Base Editor 3) and Target-AID (activation-induced cytidine deaminase), can covert C:G base pairs to T:A at target site. Here, the authors generate missense mutations of mouse Psen1 gene and find BE3 has higher editing efficiency than Target-AID.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Hiroki Sasaguri, Kenichi Nagata, Misaki Sekiguchi, Ryo Fujioka, Yukio Matsuba, Shoko Hashimoto, Kaori Sato, Deepika Kurup, Takanori Yokota, Takaomi C. Saido
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/a871c24db1bb4e74a95cf7cd649771e4
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Internet

https://doaj.org/article/a871c24db1bb4e74a95cf7cd649771e4

Documents similaires