Interference on Cytosolic DNA Activation Attenuates Sepsis Severity: Experiments on Cyclic GMP–AMP Synthase (cGAS) Deficient Mice

Interference on Cytosolic DNA Activation Attenuates Sepsis Severity: Experiments on Cyclic GMP–AMP Synthase (cGAS) Deficient Mice

Although the enhanced responses against serum cell-free DNA (cfDNA) in cases of sepsis—a life-threatening organ dysfunction due to systemic infection—are understood, the influence of the cytosolic DNA receptor cGAS (cyclic guanosine monophosphate–adenosine monophosphate (GMP–AMP) synthase) on sepsis...

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Detalles Bibliográficos
Autores principales: Peerapat Visitchanakun, Warerat Kaewduangduen, Awirut Chareonsappakit, Paweena Susantitaphong, Prapaporn Pisitkun, Patcharee Ritprajak, Natavudh Townamchai, Asada Leelahavanichkul
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
sepsis
cell free DNA
LPS
cGAS
cecal ligation and puncture
Biology (General)
QH301-705.5
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/a876e26c5e8e4df4a241dd4630b39a7f
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https://doaj.org/article/a876e26c5e8e4df4a241dd4630b39a7f

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