REV1 Inhibition Enhances Radioresistance and Autophagy

REV1 Inhibition Enhances Radioresistance and Autophagy

Cancer therapy resistance is a persistent clinical challenge. Recently, inhibition of the mutagenic translesion synthesis (TLS) protein REV1 was shown to enhance tumor cell response to chemotherapy by triggering senescence hallmarks. These observations suggest REV1’s important role in determining ca...

Full description

Saved in:
Bibliographic Details
Main Authors: Kanayo E. Ikeh, Erica N. Lamkin, Andrew Crompton, Jamie Deutsch, Kira J. Fisher, Mark Gray, David J. Argyle, Won Y. Lim, Dmitry M. Korzhnev, M. Kyle Hadden, Jiyong Hong, Pei Zhou, Nimrat Chatterjee
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
translesion synthesis
radioresistance
autophagy
REV1
ionizing radiations
etoposide
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/a8b30413ff89465cb626e026f8c27cf5
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/a8b30413ff89465cb626e026f8c27cf5

Similar Items