REV1 Inhibition Enhances Radioresistance and Autophagy

REV1 Inhibition Enhances Radioresistance and Autophagy

Cancer therapy resistance is a persistent clinical challenge. Recently, inhibition of the mutagenic translesion synthesis (TLS) protein REV1 was shown to enhance tumor cell response to chemotherapy by triggering senescence hallmarks. These observations suggest REV1’s important role in determining ca...

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Auteurs principaux: Kanayo E. Ikeh, Erica N. Lamkin, Andrew Crompton, Jamie Deutsch, Kira J. Fisher, Mark Gray, David J. Argyle, Won Y. Lim, Dmitry M. Korzhnev, M. Kyle Hadden, Jiyong Hong, Pei Zhou, Nimrat Chatterjee
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
translesion synthesis
radioresistance
autophagy
REV1
ionizing radiations
etoposide
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Accès en ligne:https://doaj.org/article/a8b30413ff89465cb626e026f8c27cf5
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https://doaj.org/article/a8b30413ff89465cb626e026f8c27cf5

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