PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates.

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Autores principales: George E. Ronson, Ann Liza Piberger, Martin R. Higgs, Anna L. Olsen, Grant S. Stewart, Peter J. McHugh, Eva Petermann, Nicholas D. Lakin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/a8b5718ddf664c57b19e95d580a3e43a
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