PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates.

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Autores principales:	George E. Ronson, Ann Liza Piberger, Martin R. Higgs, Anna L. Olsen, Grant S. Stewart, Peter J. McHugh, Eva Petermann, Nicholas D. Lakin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a8b5718ddf664c57b19e95d580a3e43a
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spelling	oai:doaj.org-article:a8b5718ddf664c57b19e95d580a3e43a2021-12-02T15:33:57ZPARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation10.1038/s41467-018-03159-22041-1723https://doaj.org/article/a8b5718ddf664c57b19e95d580a3e43a2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03159-2https://doaj.org/toc/2041-1723PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates.George E. RonsonAnn Liza PibergerMartin R. HiggsAnna L. OlsenGrant S. StewartPeter J. McHughEva PetermannNicholas D. LakinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q George E. Ronson Ann Liza Piberger Martin R. Higgs Anna L. Olsen Grant S. Stewart Peter J. McHugh Eva Petermann Nicholas D. Lakin PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
description	PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates.
format	article
author	George E. Ronson Ann Liza Piberger Martin R. Higgs Anna L. Olsen Grant S. Stewart Peter J. McHugh Eva Petermann Nicholas D. Lakin
author_facet	George E. Ronson Ann Liza Piberger Martin R. Higgs Anna L. Olsen Grant S. Stewart Peter J. McHugh Eva Petermann Nicholas D. Lakin
author_sort	George E. Ronson
title	PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
title_short	PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
title_full	PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
title_fullStr	PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
title_full_unstemmed	PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
title_sort	parp1 and parp2 stabilise replication forks at base excision repair intermediates through fbh1-dependent rad51 regulation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a8b5718ddf664c57b19e95d580a3e43a
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PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

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