High risk of early sub-therapeutic penicillin concentrations after intramuscular benzathine penicillin G injections in Ethiopian children and adults with rheumatic heart disease.

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High risk of early sub-therapeutic penicillin concentrations after intramuscular benzathine penicillin G injections in Ethiopian children and adults with rheumatic heart disease.

<h4>Introduction</h4>Intramuscular benzathine penicillin G (BPG) injections are a cornerstone of secondary prophylaxis to prevent acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Uncertainties regarding inter-ethnic and preparation variability, and target exposure profiles...

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Bibliographic Details
Main Authors:	Ezra B Ketema, Nigus Z Gishen, Abraha Hailu, Abadi Leul, Abera Hadgu, Kiflom Hagos, Samual Berhane, Temesgen Tsega, Madhu Page-Sharp, Timothy Me Davis, Brioni Moore, Kevin T Batty, Jonathan Carapetis, Sam Salman, Laurens Manning
Format:	article
Language:	EN
Published:	Public Library of Science (PLoS) 2021
Subjects:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Online Access:	https://doaj.org/article/a8be4e16c1974b01be6d3c664dcb0d1a
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